Balotelli, who struck twice against Monaco last weekend and also scored in the midweek Europa League win at Zulte-Waregem, found the top right corner from a tight angle after racing onto Alassane Plea’s pass with 10 minutes remaining.
Metz picked up their first points of the season with a 1-0 victory which ended Angers‘ unbeaten start.
Forward Nolan Roux claimed the only goal at Stade Raymond Kopa, stooping to head Mathieu Dossevi’s cross down into the ground and into the top right corner in the 55th minute.
Clinton Njie scored a quick-fire double as Marseille ended their three-game winless run in Ligue 1 with a 2-0 success at Amiens.
The former Tottenham forward converted from close range following Hiroki Sakai’s right-wing centre to break the deadlock seven minutes into the second half.
Cameroon international Njie made it five goals in four league games three minutes later, collecting a neat pass from Florian Thauvin and taking the ball past Amiens goalkeeper Regis Gurtner before slotting into the bottom right corner.